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Linear mixed effects models, using the procedure PROC MIXED in SAS software, were used to examine the effect of exposure to maternal smoking during pregnancy and childhood on height-for-age (in z-score) of the children over the three periods: at birth, preschool age (when children was zero to five years old), and at school (10 to 17 years old)

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Several animal studies have shown that nicotine exposure during adolescence causes stronger changes in the gene expression to occur within the prefrontal cortex (PFC) as compared to other periods of adulthood

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